Pituitary carcinomas and aggressive pituitary tumours: merits and pitfalls of temozolomide treatment
نویسندگان
چکیده
منابع مشابه
Temozolomide in aggressive pituitary adenomas and carcinomas
Temozolomide is an alkylating agent used in the treatment of gliomas and, more recently, aggressive pituitary adenomas and carcinomas. Temozolomide methylates DNA and, thereby, has antitumor effects. O6-methylguanine-DNA methyltransferase, a DNA repair enzyme, removes the alkylating adducts that are induced by temozolomide, thereby counteracting its effects. A Medline search for all of the avai...
متن کاملThe role of temozolomide in the treatment of aggressive pituitary adenomas and pituitary carcinomas
The role of temozolomide in the treatment of aggressive pituitary adenomas and pituitary carcinomas Except for aggressive prolactinomas, which are could be treated with dopamin agonists, surgery is the first-line treatment option for most aggressive pituitary adenomas, but usually, due to their size, invasion of surrounding tissues, and high frequency of regrowth, they are difficult to treat wi...
متن کاملTreatment of Pituitary Carcinomas and Atypical Pituitary Adenomas: A Review
Atypical pituitary adenomas (APAs) are aggressive tumors, harboring a Ki-67 (MIB-1) staining index of 3% or more, and positive immunohistochemical staining for p53 protein, according to the World Health Organization (WHO) classification in 2004. Pituitary carcinomas (PC) usually develop from progressive APAs and predominantly consist of hormone-generating tumors, defined by the presence of diss...
متن کاملPituitary tumours: pituitary incidentalomas.
Clinically non-functioning pituitary adenomas range from being completely asymptomatic, and therefore being detected either at autopsy or as incidental findings on head magnetic resonance imaging (MRI) or computed tomography (CT) scans performed for other reasons (often referred to as 'pituitary incidentalomas'), to causing significant hypothalamic/pituitary dysfunction and visual field comprom...
متن کاملUse of temozolomide in aggressive pituitary tumors: case report.
OBJECTIVE The management of aggressive pituitary macroadenomas represents a challenge to neurosurgeons. These tumors are very difficult to treat, owing mainly to their invasive nature, thus resulting in incomplete resections and propensity for recurrence. Multiple surgical procedures (transsphenoidal, transcranial, or a combination of both) are the first line management, followed by radiotherap...
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ژورنال
عنوان ژورنال: Clinical Endocrinology
سال: 2012
ISSN: 0300-0664
DOI: 10.1111/j.1365-2265.2012.04381.x